Mankin HJ. The reaction of articular cartilage to injury and osteoarthrosis (first of two parts). N Engl J Med 1974;291:1285-92.

Mankin HJ. The reaction of articular cartilage to injury and osteoarthrosis (second of two parts). N Engl J Med 1974;291:1335-40.

Pak CY, Kaplan R, Bone H et al. A simple test for the diagnosis of absorptive, resorptive and renal hypercalciurias. N Engl J Med 1975;292:497-500.

Waldvogel FA, Vasey H. Osteomyelitis: the past decade. N Engl J Med 1980;303:360-70.

Mathes SJ. The muscle flap for management of osteomyelitis. N Engl J Med 1982;306:292-5.

Reichel H, Koeffler HP, Norman AW. The role of vitamin D endocrine system in health and disease. N Engl J Med 1989;320:980-91.

Hollister DW, Godfrey M, Sakai LY et al. Immunologic abnormalities of the microfibrillar system in the Marfan Syndrome. N Engl J Med 1990;323:152-9.

Leape LL, Brennan TA, Laird N et al. The nature of adverse events in hospitalized patients (second of two parts). N Engl J Med 1991;324:377-84.

Classen DC, Evans RS, Pestotnik SL et al. The timing of prophylactic administration of antibiotics and the risk of surgical wound infection. N Engl J Med 1992;326:281-6.

Brittberg M, Lindahl A, Nilsson A et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95.

Pinals RS. Polyarthritis and fever. N Engl J Med 1994;330:769-74.

Lew DP, Waldvogel FA. Osteomyelitis. N Engl J Med 1997;336:999-1007.

White MP, Obrecht SE, Finnegan PM et al. Osteoprotegerin deficiency and Juvenile Paget’s Disease. N Engl J Med 2002;347:175-84.

2003

Wooley DE. The mast cells in inflammatory arthritis. N Engl J Med 2003;348:1709-11.

Richardson PG, Barlogie B, Berenson J et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;248:2609-17.

Whyte MP, Wenkert D, Clements KL et al. Bisphosphonate-induced osteopetrosis. N Engl J Med 2003;349:457-63.

Shattuck TM, Valimaki S, Obara T et al. Somatic and germline mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med 2003;349:1722-9.

2004

MacLaughlin DT, Donahoe PK. Sex determination and differentiation. N Engl J Med 2004;350:367-78.

Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 2004;350:482-92.

Shane E, Adesso V, Namerow PB et al. Alendronate versus calcitriol for the prevention of bone loss after cardiac transplantation. N Engl J Med 2004;350:767-76.

Bone HG, Hosking D, Devogelaer JP et al. Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 2004;350:1189-99.

Block GA, Martin KJ, de Francisco ALM et al. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004;350:1516-25.

Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004;350:1655-64.

van Meurs JBJ, Dhonukshe-Rutten RAM, Pluijm SMF et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004;350:2033-41.

Mclean RR, Jacques PF, Selhub J et al. Homocysteine as a predictive factor for hip fracture in older person. N Engl J Med 2004;350:2042-9.

Raisz LG. Homocysteine and osteoporotic fracture –culprit or bystander ? N Engl J Med 2004;350:2089-90.

Pietrangelo A. Hereditary hemochromatosis – A new look at am old disease. N Engl J Med 2004;350:2383-97.

Welt CK, Chan JL, Bullen J et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004;351:987-97.

Debers JD, Tindall DJ. Mechanisms of androgen-refractory prostate cancer. N Engl J Med 2004;351:1488-90.

Zimmerli W, Trampuz A, Ochsner PE. Prostetic-joint infections. N Engl J Med 2004;351:1645-54.

Tolar J, Teitelbaum SL, Orchard PJ. Osteopetrosis. N Engl J Med 2004;351:2839-49.

2005

Shahinian VB, Kuo Y-F, Freeman JL et al. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med 2005;352:154-64.

Steward AF. Hypercalcemia associated with cancer. N Engl J Med 2005;352:373-9.

Silverman E, Mouy R, Spiegel L et al. Leflunomide or methotrexate for juvenile Rheumatoid Arthritis. N Engl J Med 2005;352:1655-66.

Liu Y-F, Chen W-M, Lin Y-F et al. Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Engl J Med 2005;352:2294-2301.

Eghbali-Fatourechi GZ, Lamsam J, Frase D et al. Circulating osteoblast-lineage cell in humans. N Engl J Med 2005;352:1959-66.

Canalis E. The fate of circulating osteoblasts. N Engl J Med 2005;352:2014-6.

Maerevoet M, Martin C, Duck L. Osteonecrosis ofthe iaw and bisphosphonates. N Engl J Med 2005;353:99-102.

Raisz LG. Screening for osteoporosis. N Engl J Med 2005;353:164-71.

Karsenty G. An aggrecanase and osteoarthritis. N Engl J Med 2005;353:522-3.

Black DM, Bilezikian JP, Ensrud KE et al. One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis. N Engl J Med 2005;353:555-65.

Cosman F, Nieves J, Zion M et al. Daily and cyclic parathyroid hormone in women receiving alendronate. N Engl J Med 2005;353:566-75.

Heaney RP, Recker RR. Combination and sequential therapy for osteoporosis. N Engl J Med 2005;353:624-5.

Cundy T, Davidson J, Rutland MD et al. Recombinant osteoprotegerin for Juvenile Paget’s Disease. N Engl J Med 2005;353:918-23.

Rhen T, Cidlowski JA. Antinflammatory action  of glucocorticoids – new mechanisms for old drugs. N Engl J Med 2005;353:1711-23.

Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005;353:1261-73.

Petri M, Kim MY, Kalunian KC et al. Combined oral contraceptive in women with systemic lupus erythematosus. N Engl J Med 2005;353:2550-8.

2006

Firestein GS. Inhibiting inflammation in Rheumatoid Arthritis. N Engl J Med 2006;354:80-2.

Jackson RD, LaCroix AZ, Gass M et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-83.

Finkelstein JS. Calcium plus vitamin D for postmenopausal women – bone appetit ? N Engl J Med 2006;354:750-2.

McClung MR, Lewiecki EM, Cohen SB et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 2006;354:821-31.

Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 2006;345:1387-1401.

Berman E, Nicolaides M, Maki RG et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006;354:2006-13.

Seeman E, Delmas PD. Bone quality – the material and structural basis of bone strength and fragility. N Engl J Med 2006;354:2250-61.

Marcus EN. The silent epidemic – the health effects of illiteracy. N Engl J Med 2006;355:339-41.

Whyte MP. Paget’s disease of bone. N Engl J Med 206;355:593-600.

Drenth JPH, van der Meer JWM. The inflammasome – a linebacker of innate defense. N Engl J Med 2006;355:730-2.

Goldback-Masky R, Dailey NJ, Canna SW et al. Neonatal onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition. N Engl J Med 2006;355:581-92.

Loeys BL, Schwarze U, Holm T et al. Aneurysm syndromes caused by mutations in the TGFbeta receptor. N Engl J Med 2006;355:788-98.

Gelb BD. Marfan’s syndrome and related disorders – more tightly connected than we thought. N Engl J Med 2006;355:841-4.

Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med 2006;355:1345-56.

Nair KS, Rizza RA, O’Brien P et al. DHEA in elderly women and DHA and Testosterone in elderly men. N Engl J Med 2006;355:1647-59.

Bilezikian JP. Osteonecrosis of the jaw – do bisphosphonates pose a risk ? N Engl J Med 2006;355:2278-81.

Barnes AM, Chang W, Morello R et al. Deficiency of cartilage-associated protein in recessive lethal Osteogenesis Imperfecta. N Engl J Med 2006;355:2757-64.

2007

Huttenlocher A, Horwitz AR. Wound healing with electric potential. N Engl J Med 2007;356:303-4.

Tonetti MS, D’Aiuto F, Nibali L et al. Treatment of periodontitis and endothelial function. N Engl J Med 2007;356:911-20.

Jin Y, Mailloux CM, Gowan K et al. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med 2007;356:1216-25.

Gregersen PK. Modern genetics, ancient defenses, and potential therapies. N Engl J Med 2007;356:1263-6.

Larsen CM, Faulenbach M, Vaag A et al. Interleukin-1 receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007;356:1517-26.

Black DM, Delmas PD, Eastell R et al. Once-yearly Zolendronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007;356:1809-22.

Khosla S, Melton LJ III. Osteopenia. N Engl J Med 2007;356:2293-300.

Lipsky PE. Why does rheumatoid arthritis involve the joints ? N Engl J Med 2007;356:2419-20.

Haas D, Hoffmann GF. Mevalonate kinase deficiency and autoinflammatory disorders. N Engl J Med 2007;356:2671-3.

Neven B, Valayannopoulos V, Quartier P et al. Allogenic bone marrow transplantation in mevalonic aciduria. N Engl J Med 2007;356:2700-3.

Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.

Yates JRW, Sepp T, Matharu BK et al. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med 2007;357:553-61.

Drazen JM, Phimister EG. Publishing genomewide association studies. N Engl J Med 2007;357:496.

Barabasi AL. Network Medicine – From obesity to diseasome. N Engl J Med 2007;357:404-7.

Hunter DJ, Kraft P. Drinking from the fire hose – statistical issues in genomewide association studies. N Engl J Med 2007;357:436-9.

Canalis E, Giustina A, Bilezikian JP. Mechanism of anabolic therapies for osteoporosis. N Engl J Med 2007;357:905-16.

Plenge RM, Seielstad M, Padyukov L et al. TRAF1-C5 as a risk locus for Rheumathoid Arthritis – A genomewide study. N Engl J Med 2007;357:1199-209.

Remmers EF, Plenge RM, Lee AT et al. STAT4 and the risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus. N Engl J Med 2007;357:977-86.

Peter-Golden M, Henderson WR. Leukotrienes. N Engl J Med 2007;357:1841-54.

Calis KA, Pucino F. Zolendronic acid and secondary prevention of fractures. N Engl J Med 2007;357:1861-2.

Saag KG, Shane E, Boonen S et al. Teriparatide or alendronate in glucocorticoid induced osteoporosis. N Engl J Med 2007;357:2028-39.

2008

Allen KJ, Gurrin LC, Constantine CC et al. Iron-overload related disease in HFE hereditary hemochromatosis. N Engl J Med 2008;358:221-30.

Hom G, Graham RR, Modrek B et al. Association of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008;358:900-9.

Rahman A, Isenberg DA. Systemic Lupus Erythematosus. N Engl J Med 2008;358:929-39.

Lenart BA, Lorich DG, Lane JM. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med 2008;358:1304-6.

Matsen FA III. Rotator-cuff failure. N Engl J Med 2008;358:2138-47.

Styrkarsdottir U, Halldorsson BV, Gretarsdottir S et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med 2008;358:2355-65.

Ebeling PR. Osteoporosis in men. N Engl J Med 2008;358:1474-82.

Brooke BS, Habashi JP, Judge DP et al. Angiotensin II blockade and aortic root dilatation in Marfan’s syndrome. N Engl J Med 2008;358:2787-95.

Shoback D. Hypoparathyroidism. N Engl J Med 2008;359:391-403.

Gutierrez OM, Mannstadt M, Isakova T et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008;359:584-92.

Hsu C. FGF-23 and outcomes research – when physiology meets epidemiology. N Engl J Med 2008;359:640-2.

Weiss LA, Shen Y, Korn JM et al. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 2008;359:667-75.

Han JC, Liu QR, Jones MP et al. Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med 2008;359:918-27.

Karim Z, Gerard B, Bakouh N et al. NHERF1 mutations and responsiveness of renal parathyroid hormone. N Engl J Med 2008;359:1128-35.

Nachman RL, Rafii S. Platelets, petecchiae, and preservation of the vascular wall. N Engl J Med 2008;359:1261-70.

Rossebo AB, Pedersen TR, Boman K et al. Intensive lipid lowering withsimvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008;359:1343-56.

Mefford H, Sharp A, Baker C et al. Recurrent rearrangements of chromosome 1q21.1and variable pediatric phenotypes. N Engl J Med 2008;359:1658-99.

Davis SR, Moreau M, Kroll R et al. Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 2008;359:2005-17.

2009

Weinstein RS, Roberson PK, Manolagas SC. Giant osteoclast formation and long-term oral bisphosphonate therapy. N Engl J Med 2009;360:53-62.

Bulun SE. Endometriosis. N Engl J Med 2009;360:268-79.

Gnant M, Mlineritsch B, Schippinger W et al. Endocrine therapy plus zolendronic acid in premenopausal breast cancer. N Engl J Med 2009;360:679-91.

Rosen CJ. Serotonin rising – The bone, brain, bowel connection. N Engl J Med 2009;360:957-9.

Laurenco D, Brauner R, Lin L et al. Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med 2009;360:1200-9.

Leopold SS. Minimally invasive total knee arthroplasty for osteoarthritis. N Engl J Med 2009;360:1749-58.

Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med 2009;360:1989-2003.

Noordam C, Dhir V, McNelis JC et al. Inactivating PAPSS2 mutations in a patients with premature pubarche. N Engl J Med 2009;360:2310-8.

Harousseau JL, Moreau P. Autologous hematopoietic stem cell transplantation for multiple myeloma. N Engl J Med 2009;360:2645-54.

Buchbinder R, Osborne RH, Ebeling PR et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 2009;361:557-68.

Kallmes DF, Comstock BA, Heagerty PJ et al. A randomzed trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 2009;361:569-79.

Smith MR, Egerdie B, Toriz NH et al. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 2009;361:745-55.

Cummings SR, Martin JS, McClung MR et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009;361:756-65.

Mardis ER, Ding L, Dooling DJ et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009;361:1058-66.

Downing JR. Cancer genome. Continuing progress. N Engl J Med 2009;361:1111-2.

Riches PL, McRorie E, Fraser WD et al. Osteoporosis associated with neutralizing antibodies against osteoprotegerin. N Engl J Med 2009;361:1459-65.

Frulloni L, Lunardi C, Simone R et al. Identification of a novel antibody associated with autoimmune pancreatitis. N Engl J Med 2009;361:2135-42.

2010

Markowitz SD, Bertagnolli MM. Molecular basis of colorectal cancer. N Engl J Med 2009;361:2449-60.

Smits P, Bolton AD, Funari V et al. Lethal Dysplasia in mice and humans lacking the Golgin GMAP-210. N Engl J Med 2010;362:206-16.

Barnes AM, Carter EM, Cabral WA et al. Lack of cyclophillin B in Osteogenesis Imperfecta with normal collagen folding. N Engl J Med 2010;362:521-8.

Cummings SR, Ensrud K, Delmas PD et al. Lasofoxifene in postmenopausal women with osteoporosis. N Engl J Med 2010;362:686-96.

Zimmerli W. Vertebral Osteomyelitis. N Engl J Med 2010;362:1022-9.

Magen D, Berger L, Coady MJ et al. A loss of function mutation in NaPiIIa and renal Fanconi’s syndrome. N Engl J Med 2010;362:1102-9.

Black DM, Kelly MP, Genant HK et al. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med 2010;362:1761-71.

Maris JM. Recent advances in Neuroblastoma. N Engl J Med 2010;362:2202-10.

Priè D, Friedlander G. Genetic disorders of renal phosphate transport. N Engl J Med 2010;362:2399-2409.

Wu FCW, Tajar A, Beynon JM et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010;363:123-5.

Gordon CM. Functional hypothalamic amenorrhea N Engl J Med 2010;363:365-71.

The ACCORD Study Group and ACCORD Eye Study Group. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 2010;363:233-44.

Wang C, Schmid CH, Rones R et al. A randomized trial of Tai Chi for Fibromyalgia. N Engl J Med 2010;363:743-54.

Flaherty KT, Puzanov I, Kim KB et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-19.

Lane NE, Schnitzer TJ, Birbara CA et al. Tanezumab for the treatement of pain from osteoarthritis of the knee. N Engl J Med 2010;363:1521-31.

Favus MJ. Bisphosphonates for osteoporosis. N Engl J Med 2010;363:2027-35.

2011

Bashutski JD, Eber RM, Kinney JS et al. Teriparatide and osseous regeneration in the oral cavity. N Engl J Med 2010;363:2396-405.

Chahal HS, Stals K, Unterlander M et al. AIP mutation in pituitary adenomas in the 18th Century and Today. N Engl J Med 2011;364:43-50.

Caronia LM, Martin C, Welt CK et al. A genetic basis for functional Hypothalamic Amenorrhea. N Engl J Med 2011;364:215-25.

Hara Y, Balci-Hayta B, Yoshida-Moriguchi T et al. A dystroglycan mutation associated with limb-girdle muscular dystrophy. N Engl J Med 2011;364:939-46.

Ensrund KE, Schousboe JT. Vertebral fractures. N Engl J Med 2011;364:1634-42.

Marcocci C, Kahaly GJ, Krasses GE et al. Selenium and the course of mild Graves’ orbitopathy. N Engl J Med 2011;364:1920-31.

Schlingmann KP, Kaufmann M, Weber S et al. Mutations in CYP24A1 and Idiopathic Infantile Hypercalcemia. N Engl J Med 2011;365:410-21.

Patel MR, Mahaffey KW, Garg J et al. Rivaroxaban versus Warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883-91.

Irvine AD, McLean I, Leung DYM. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011;365:1315-27.

Pramyothin P, Leung AM, Pearce EN et al. A hidden solution. N Engl J Med 2011;365:2123-7.